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Glucoraphanin
Plant sources:Glucoraphanin, sourced from annual or biennial herbaceous plants of the genus Brassica (Brassicaceae family), particularly the vegetable cultivar broccoli (Brassica oleracea L. var. italica Plenck), is a thioglucoside with the molecular formula C₁₂H₂₃NO₁₀S₂. Upon hydrolysis by the enzyme myrosinase, glucoraphanin is converted to sulforaphane (molecular formula: C₆H₁₁NOS₂).
[1] Li X, Wang Y, Zhao G, et al. Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane. Foods. 2022;11(23):3775.
[2] Arcidiacono P, Ragonese F, Stabile A, et al. Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells. Eur J Nutr. 2018;57(7):2547-2569.
[3] Pu Y, Qu Y, Chang L, et al. Dietary intake of glucoraphanin prevents the reduction of dopamine transporter in the mouse striatum after repeated administration of MPTP. Neuropsychopharmacol Rep. 2019;39(3):247-251.
[4] Fujita Y, Fujita A, Ishima T, et al. Dietary intake of glucoraphanin during pregnancy and lactation prevents behavioral abnormalities in offspring after maternal immune activation. Neuropsychopharmacol Rep. 2020;40(3):268-274.
[5] Nagata N, Xu L, Kohno S, et al. Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Diabetes. 2017;66(5):1222-1236.
[6] Otoo RA, Allen AR. Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action. Molecules. 2023;28(19):6902.
[7] Ordonez AA, Bullen CK, Villabona-Rueda AF, et al. Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice. Commun Biol. 2022;5(1):242.
[8] Mazarakis N, Higgins RA, Anderson J, et al. The effects of the dietary compound L-sulforaphane against respiratory pathogens. Int J Antimicrob Agents. 2021;58(6):106460.

