Amid the rapid advancement of life sciences and medical technologies, liposome technology has emerged as a highly promising cutting-edge field, becoming a research focus in pharmaceuticals, nutraceuticals, cosmetics, and other industries. With its unique structure and properties, liposomes offer innovative solutions to longstanding challenges such as low drug delivery efficiency, poor nutrient stability, and insufficient penetration of active ingredients in traditional technologies, driving technological breakthroughs and industrial upgrading across multiple sectors.

Concept of Liposome Technology 

Liposomes are prepared nanoscale vesicles primarily composed of phospholipids and other lipids. Phospholipid molecules possess an amphiphilic structure—hydrophilic heads and hydrophobic tails—that spontaneously assemble into bilayer-enclosed vesicles in aqueous environments. This structure closely resembles biological cell membranes, endowing liposomes with excellent biocompatibility. They can encapsulate water-soluble, lipid-soluble, and amphiphilic substances, serving as efficient carrier systems. The core structure of liposomes is the phospholipid bilayer, with hydrophilic heads facing outward (in contact with the aqueous phase) and hydrophobic tails forming a hydrophobic core inward. Cholesterol and other regulatory components can be incorporated into the bilayer to modulate membrane fluidity and stability: preventing membrane rigidity at low temperatures and maintaining integrity at high temperatures. This structure allows liposomes to encapsulate substances of different properties in the aqueous phase and the hydrophobic core, laying the foundation for their application as functional carriers.

                                       Figure 1 The Formation of Liposomes.

Classification of Liposome Technology 

Liposomes are generally classified into three categories based on their structure: unilamellar liposomes, which consist of a single bilayer and are divided into small unilamellar vesicles (20-80 nm) with good permeability and stable in vivo circulation, and large unilamellar vesicles (100 nm-1 μm) that offer a large encapsulation volume suitable for high drug-loading scenarios; multilamellar liposomes, featuring an "onion-like" structure composed of multiple bilayers with a particle size of 1-5 μm, whose internal multi-compartment spaces provide high encapsulation capacity, enabling slow drug release and long-acting sustained-release properties; and multivesicular liposomes, which are non-concentric vesicles with a particle size of 5-50 μm, containing multiple independent internal vesicles that ensure high encapsulation volume and low leakage, making them particularly suitable for encapsulating water-soluble drugs.

Applications of Liposome Technology 

In the application of liposome technology, the pharmaceutical field leverages liposomes for tumor therapy (passive/active targeting via EPR effect and antibody modification to reduce tissue damage and toxicity, with clinically effective examples like doxorubicin and paclitaxel liposomes), anti-inflammatory/anti-infective treatments (e.g., rifampicin liposome aerosols enhancing pulmonary drug retention, ketoconazole liposomes improving solubility and reducing hepatotoxicity), ocular disease therapy (overcoming corneal barriers to boost bioavailability), neurodegenerative disease treatment (modified liposomes crossing the blood-brain barrier for precise drug delivery), and antimalarial therapy (enhancing drug stability and reducing resistance); the nutraceutical field uses liposomes to improve nutrient stability (isolating external factors) and bioavailability (e.g., silymarin absorption increasing nearly 50-fold, liposomal vitamin C and curcumin having 8x and 107.5x higher absorption respectively); the cosmetics field employs liposomes to protect active ingredients from oxidation, enable deep skin penetration and sustained release, with applications like liposomal hyaluronic acid essence and eye creams improving skincare efficacy.

                          Figure 2 A Comprehensive Framework for the Evaluation of Liposomes.

Advantages and Challenges of Liposome Technology 

Liposomes offer advantages such as a wide drug-loading range, diverse administration routes, strong targeting ability, excellent long-acting performance, superior biocompatibility, reduced drug toxicity, and enhanced stability; they can encapsulate hydrophilic, lipophilic, and amphiphilic substances, adapt to both small-molecule and biomacromolecular drugs, support multiple administration methods including injection, oral intake, ocular, pulmonary, and transdermal delivery, naturally possess liver-spleen targeting, and can achieve precise targeting of specific tissues or cells through modification, while extending in vivo circulation time and enabling sustained drug release with technologies like PEGylation; their cell membrane-like structure helps reduce body irritation and immunogenicity, minimizes drug accumulation in organs such as the heart and kidneys to improve treatment safety, and protects drugs from external factors like oxidation and hydrolysis; however, their development still faces challenges including high preparation costs, poor stability during storage and in vivo, and complex in vivo metabolic mechanisms.

         Figure 3 The Determinants of Corporate Competitive Advantage.

Summary and Outlook 

Centered on phospholipid bilayer vesicles, liposome technology has enabled precise drug delivery and toxicity reduction in pharmaceuticals, improved nutrient absorption in nutraceuticals, and enhanced transdermal efficacy of active ingredients in cosmetics. It has become a key supporting technology driving industrial upgrading across multiple sectors. Future development will focus on researching novel liposomes to improve drug-loading capacity, stability, and targeting; innovating processes to reduce production costs and promote large-scale application; and expanding application scope to emerging fields such as gene therapy, vaccine development, and agricultural environmental protection. This will continue to unlock technological potential, providing innovative solutions for various industries.

Product Transformation of Liposome Technology

Our company has successfully established a liposome product matrix covering multiple health dimensions including antioxidant, anti-aging, liver protection, sleep regulation, and immune enhancement, with core products including liposomal glutathione, liposomal cherry powder, liposomal NMN, liposomal NAD+, liposomal vitamin C, liposomal grape seed extract, liposomal melatonin, liposomal silymarin, liposomal resveratrol, liposomal coenzyme Q10, liposomal curcumin, liposomal dihydromyricetin, liposomal quercetin, liposomal rutin, and liposomal berberine hydrochloride.

Figure 4 List of the Company's Main Products.

All products adopt high-purity active ingredients as core raw materials and rely on patented liposome preparation processes to precisely address the key pain points of traditional formulations in applications. For oxidation-prone and inactivation-susceptible ingredients such as glutathione and vitamin C, liposome encapsulation effectively isolates the external environment, significantly improving ingredient stability and active retention rate; for ingredients with low bioavailability like NMN and resveratrol, the liposome structure promotes their transmembrane absorption and cellular delivery, achieving a leapfrog improvement in bioavailability; for ingredients such as berberine hydrochloride that may cause gastrointestinal discomfort, liposome encapsulation greatly reduces direct irritation, improves human tolerance, and provides consumers with more reliable and efficient health solutions. Currently, the company's products cover pharmaceuticals, nutraceuticals, pharmaceutical intermediates, and other fields. Through systematic formulation innovation, the company's products have formed differentiated advantages in multiple dimensions and have become one of the leading suppliers of liposome raw materials and finished product solutions in China.